Vitamin C, Cancer, and Dr. Linus Pauling - Cancer MonthlyVitamin C, Linus Pauling was right all along. A doctor's opinion Published on August 17, Summary It is the 10th anniversary of the death of Linus Pauling and his most controversial scientific conjectures about the health benefits of vitamin C are being confirmed. The weight of evidence may yet force the medical establishment to accept his ideas on nutrition and health. Linus Pauling's claim, that he knew a cure for heart disease , cancer and infections, was greeted with ridicule. His remarkable health claims concerned the substance we know as vitamin C. Now, ten years after his death on 19th August , his revolutionary ideas are finally on the way to vindication.
Vitamin C, Linus Pauling was right all along. A doctor's opinion
Results from another study by the same investigators suggested that vitamin C could not prevent the oxidation of high-density lipoprotein HDL - cholesterol by glycated Hb-Hp complexes in vitro nor restore impaired HDL function in diabetic mice carrying the Hp genotype She also used other alternative therapies, hair and tooth loss, including: thymus protein extract. What you need to know about chemotherapy. Symptoms of scurvy include subcutaneous bl.Michels, Ph. A meta-analysis of 44 randomized controlled trials in subjects with or without chronic diseases summarized the effect of supplemental vitamin C on endothelial function by measuring FMD 19 studiesmatched controls about half of the controls were in the original set 3, or by pulse wave analysis 5 trials According to an investigative fitamin by James Lowell. A second study was performed in with new ascorbate-treated patients and 1.
A number of observational studies have found increased dietary vitamin C intake to be associated with decreased risk of gastric stomach cancerplacebo -controlled trial has examined the effect of intravenous vitamin C administered to patients with stable angina undergoing elective coronary angioplasty. Another trial randomized patients to receive a 3-g vitamin C infusion or a placebo saline solution within six hours prior to coronary angioplasty One randomizedand laboratory experiments indicate that vitamin C inhibits the formation of carcinogenic N-nitroso compounds in the stomach Contemp Clin Trials.
Vitamin C whether intravenous or oral is one of the most prevalent types of alternative and complimentary cancer therapies. Since two time Nobel Prize winner in chemistry and peace Dr. In this article, we review the history of this nutrient in cancer, the controversy, and discuss current findings.
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Four phase I clinical trials in patients with advanced cancer found that intravenous administration of vitamin C at doses up to 1. In contrast, trials are intervention studies that can establish a causal relationship between an exposure and an outcome. Namespaces Article Talk. Because vitamin C can inactivate urease an enzyme that facilitates H.
Several cross-sectional studies have reported an inverse association between vitamin C status and blood lead concentration. It is widely thought by the general public that vitamin C boosts immune function, and laboratory experiments indicate that vitamin C inhibits the formation of carcinogenic N-nitroso compounds in the stomach. Retrieved 31 July A number of observational studies have found increased dietary vitamin C intake to be associated with decreased risk of gastric stomach canceryet human studies published to date are conflicting?
Linus Pauling, Ph. He received these awards for chemistry in and for peace in He contributed greatly to the development of chemical theories. His impact on the health marketplace, however, was anything but laudable. Pauling is largely responsible for the widespread misbelief that high doses of vitamin C are effective against colds and other illnesses. In , he postulated that people's needs for vitamins and other nutrients vary markedly and that to maintain good health, many people need amounts of nutrients much greater than the Recommended Dietary Allowances RDAs.
Retrieved Combined effect of metformin with ascorbic pailing versus acetyl salicylic acid on diabetes-related cardiovascular complication; a month single blind multicenter randomized control trial. Vitamin C concentrations in plasma as a function of intake: a meta-analysis. The evidence for these claims is mixed. The Site and Content are protected by the copyright and trademark laws of the United States and other countries, and other applicable laws.
This work follows a number of articles by the same group, led by Mark Levine at the National Institute of Diabetes and Digestive and Kidney Diseases, showing that millimolar concentrations of extracellular vitamin C kill cancer cells but not normal cells in a hydrogen peroxide H 2 O 2 -dependent manner 1 — 3. Such millimolar concentrations of vitamin C can be achieved in humans by i. Hence, vitamin C is postulated to exert local pro-oxidant effects in the interstitial fluid surrounding tumor cells, killing them or inhibiting their growth, while leaving normal cells intact 1 — 3. It is well known that vitamin C, or ascorbic acid, is an effective biologic antioxidant and does not act as a pro-oxidant under normal conditions 5 because it does not readily autoxidize, i. In fact, reduction of copper or iron in the catalytic site of certain enzymes underlies ascorbate's well known biologic function as a co-substrate in procollagen, carnitine, and catecholamine biosynthesis 6. Reduced transition metal ions, in contrast to ascorbic acid, readily react with O 2 , reducing it to superoxide radicals Reaction 2 , which in turn dismutate to form H 2 O 2 and O 2 Reaction 3 :.
Cancer statistics in China. Comparison of the absorption and excretion of three commercially available sources of vitamin C. Finallyvitamin C increases the bioavailability of iron from foods by enhancing intestinal absorption of non- heme iron see the article on Iron Yet.
Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes. Am J Epidemiol. Vitamin C supplementation for the primary prevention of cardiovascular disease. Linus Pauling's recommendations and the Linus Pauling Institute's recommendation for vitamin C intake.